2,6-二氯嘌呤合成路线

参考文献

Bhakuni, D. S.; Gupta, P. K.; Chowdhury, B. L.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1286 - 1288

5451-40-12,6-二氯嘌呤+

74-88-4甲基碘

2382-10-72,6-二氯-9-甲基-9H-嘌呤+

2273-93-02,6-二氯-7-甲基嘌呤

参考文献

WO2005/28479 A2, ;

Page/Page column 58 ;

5451-40-12,6-二氯嘌呤

1839-18-52-氯-6-氨基嘌呤

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/101867 A1, 2008 ;
Location in patent: Page/Page column 84 ;

参考文献

Journal of Organic Chemistry, , vol. 48, # 8 p. 1207 - 1210

5451-40-12,6-二氯嘌呤+

67-63-0异丙醇

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

Lu, Weibing; Sengupta, Sujata; Petersen, Jeffrey L.; Akhmedov, Novruz G.; Shi, Xiaodong
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 5012 - 5015

75-30-92-碘代丙烷+

5451-40-12,6-二氯嘌呤

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

Liang, Mary; Tarr, Tyler B.; Bravo-Altamirano, Karla; Valdomir, Guillermo; Rensch, Gabriel; Swanson, Lauren; Destefino, Nicholas R.; Mazzarisi, Cara M.; Olszewski, Rachel A.; Wilson, Gabriela Mustata; Meriney, Stephen D.; Wipf, Peter
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 12 p. 985 - 990

75-26-32-溴丙烷+

5451-40-12,6-二氯嘌呤

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

N'Gompaza-Diarra, Joannah; Bettayeb, Karima; Gresh, Nohad; Meijer, Laurent; Oumata, Nassima
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 210 - 216

5451-40-12,6-二氯嘌呤+

75-26-32-溴丙烷

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

Oumata, Nassima; Bettayeb, Karima; Ferandin, Yoan; Demange, Luc; Lopez-Giral, Angela; Goddard, Marie-Lorene; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Flajolet, Marc; Greengard, Paul; Meijer, Laurent; Galons, Herve
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5229 - 5242

67-63-0异丙醇+

5451-40-12,6-二氯嘌呤

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

Zatloukal, Marek; Jorda, Radek; Gucky, Tomas; Reznickova, Eva; Voller, Jiri; Pospisil, Tomas; Malinkova, Veronika; Adamcova, Helena; Krystof, Vladimir; Strnad, Miroslav
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 61 - 72

5451-40-12,6-二氯嘌呤

203436-45-72,6-二氯-9-异丙基-9h-嘌呤

参考文献

Aventis Pharmaceuticals Inc.
Patent: US6413974 B1, 2002 ;
US 6413974 B1