4-氨基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 10 条）
反应条件
palladium in methanol
参考文献
The Procter and Gamble Company
Patent: US6162818 A1, 2000 ;
US 6162818 A
反应条件
palladium on activated charcoal; hydrogen in methanol
2.) reflux, 72 h;
参考文献
Goetz, Frederick J.; Hirsch, Jerry A.; Augustine, Robert L.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2468 - 2472
参考文献
Mewshaw, Richard E.; Verwijs, Antoine; Shi, Xiaojie; McGaughey, Georgia B.; Nelson, James A.; Mazandarani, Hossein; Brennan, Julie A.; Marquis, Karen L.; Coupet, Joseph; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2675 - 2680
反应条件
toluene-4-sulfonic acid in ethanol; N,N-dimethyl-formamide
2 h; Reflux;
参考文献
Pharmeste S.r.l.
Patent: EP2377850 A1, 2011 ;
Location in patent: Page/Page column 23; 33 ;
反应条件
1: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating
2: 94 percent / 10percent palladium on carbon, H2 / methanol / 2.) reflux, 72 h
View Scheme
参考文献
Goetz, Frederick J.; Hirsch, Jerry A.; Augustine, Robert L.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2468 - 2472
反应条件
1: 1.) potassium tert-butoxide / 1.)DMF, 2.) 20 to 90 deg C, 2 h, 25 deg C, 16 h, to 10 deg C
2: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating
3: 94 percent / 10percent palladium on carbon, H2 / methanol / 2.) reflux, 72 h
View Scheme
参考文献
Goetz, Frederick J.; Hirsch, Jerry A.; Augustine, Robert L.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2468 - 2472
反应条件
1: 92 percent / SnCl2, aq. HCl
2: 78 percent / Raney Ni / ethanol
View Scheme
参考文献
Mewshaw, Richard E.; Verwijs, Antoine; Shi, Xiaojie; McGaughey, Georgia B.; Nelson, James A.; Mazandarani, Hossein; Brennan, Julie A.; Marquis, Karen L.; Coupet, Joseph; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2675 - 2680
反应条件
1: 1.) SO2Cl2, 2.) NEt3
2: 92 percent / SnCl2, aq. HCl
3: 78 percent / Raney Ni / ethanol
View Scheme
参考文献
Mewshaw, Richard E.; Verwijs, Antoine; Shi, Xiaojie; McGaughey, Georgia B.; Nelson, James A.; Mazandarani, Hossein; Brennan, Julie A.; Marquis, Karen L.; Coupet, Joseph; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2675 - 2680
反应条件
1: acetic acid / 5 h
2: acetic acid; SnCl2·2H2O / ethanol / 7 h / 70 °C / |Inert atmosphere
3: Raney Nickel / ethanol / 2 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
ANNJI PHARMACEUTICAL CO., LTD.; Chern, Ji-Wang; Jagtap, Ajit Dhananjay; Wang, Hsiao-Chun; Chen, Grace Shiahuy
Patent: US2013/281451 A1, 2013 ;
反应条件
hydrogenchloride; tin
参考文献
ICI
Patent: US2872372 , 1957 ;
