吡啶-2.6-二羧酸二甲酯合成路线 （共 63 条）
反应条件
iron sulphate heptahydrate; sulfuric acid; dihydrogen peroxide in water
T=0 - 20°C;
参考文献
Labbe, Genevieve; Krismanich, Anthony P.; De Groot, Sarah; Rasmusson, Timothy; Shang, Muhong; Brown, Matthew D.R.; Dmitrienko, Gary I.; Guillemette, J. Guy
Journal of Inorganic Biochemistry, 2012 , vol. 112, p. 49 - 58
反应条件
1: With sodium amide in tetrahydrofuran
Claisen condensation; Inert atmosphere;
2: With hydrogenchloride; water in tetrahydrofuran
Claisen condensation; Inert atmosphere;
参考文献
Bauer, Walter; Hampel, Frank; Maid, Harald
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2010 , vol. 65, # 3 p. 273 - 280
反应条件
1: KOH / methanol / 1 h
2: SOCl2 / tetrahydrofuran / 20 °C
3: diethyl ether / 0 °C
4: conc. NH4OH / 20 °C
View Scheme
参考文献
Kelly, T. Ross; Echavarren, Antonio; Chandrakumar, Nizal S.; Koeksal, Yetkin
Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2127 - 2130
反应条件
1: KOH / methanol / 1 h
2: SOCl2 / tetrahydrofuran / 20 °C
3: diethyl ether / 0 °C
4: conc. NH4OH / 20 °C
5: 1.) THF, 0 deg C, 1 h; 2.) 0 deg C, 15 min, 1 equiv. of CH3OCH2N=C=S
View Scheme
参考文献
Kelly, T. Ross; Echavarren, Antonio; Chandrakumar, Nizal S.; Koeksal, Yetkin
Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2127 - 2130
反应条件
1: 85 percent / KOH / methanol / 2 h / 0 °C
2: 22.0 g / oxalyl chloride; DMF / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Ong, Wei Qiang; Zhao, Huaiqing; Du, Zhiyun; Yeh, Jared Ze Yang; Ren, Changliang; Tan, Leon Zhen Wei; Zhang, Kun; Zeng, Huaqiang
Chemical Communications, 2011 , vol. 47, # 22 p. 6416 - 6418
反应条件
1: 85 percent / NaBH4 / methanol / 4 h / 20 °C
2: 74 percent / MnO2 / acetone
3: 72 percent / aq. KOH / tetrahydrofuran
View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol; water
120 h;
参考文献
AstraZeneca AB; NPS Pharmaceuticals
Patent: US2007/37816 A1, 2007 ;
Location in patent: Page/Page column 41 ;
US 20070037816 A1
反应条件
hydrazine hydrate in ethanol
Heating;
参考文献
Wang, Changsheng; Jung, Gun-Young; Batsanov, Andrei S.; Bryce, Martin R.; Petty, Michael C.
Journal of Materials Chemistry, 2002 , vol. 12, # 2 p. 173 - 180
反应条件
NH2NH2 (98percent) in methanol
18 h; Heating;
参考文献
Xu, Zhiqiang; Thompson, Laurence K.; Miller, David O.
Journal of the Chemical Society. Dalton Transactions, 2002 , # 12 p. 2462 - 2466
反应条件
4 A molecular sieve; potassium methanolate in methanol
Product distribution;
参考文献
Bradshaw, Jerald S.; Jones, Brian A.; Nielsen, Ralph B.; Spencer, Neil O.; Thompson, Patricia K.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 957 - 962
