2-苯基氨基亚甲基-丙二酸二乙酯合成路线 （共 32 条）
反应条件
1: diethyl ether 2: water View Scheme
参考文献
Chemische Berichte, , vol. 30, p. 1757
反应条件
in diethyl ether Ambient temperature;
参考文献
Gazzetta Chimica Italiana, , vol. 104, p. 715 - 729
参考文献
Justus Liebigs Annalen der Chemie, , vol. 285, p. 140
Chemische Berichte, , vol. 27, p. 2744
参考文献
Chemische Berichte, , vol. 30, p. 1757
参考文献
Chemische Berichte, , vol. 30, p. 1757
反应条件
in diphenylether T=190°C; 0.416667 h; Microwave irradiation;
参考文献
Cao, Xin; You, Qi-Dong; Li, Zhi-Yu; Yang, Yan; Wang, Xiao-Jian
Synthetic Communications, 2009 , vol. 39, # 24 p. 4375 - 4383
反应条件
1: 25 percent / diphenyl ether 2: 99 percent / NaOH / H2O View Scheme
参考文献
Riegel et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1264
反应条件
1: PPA; trichlorophosphate 2: sodium hydroxide View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1.1: diphenylether; ethanol / 3.5 h / 228 - 232 °C / Inert atmosphere 2.1: sodium hydroxide; water / ethanol / 16 h / Reflux 2.2: 20 - 25 °C / pH 2 - 3 3.1: pyridine; 1-propanephosphonic acid cyclic anhydride / 2-methyl tetrahydrofuran / 8 h / 47.5 °C 4.1: sodium methylate / 2-methyl tetrahydrofuran; methanol / 1 h / 25 °C 4.3: 78 °C View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; VERWIJS, Marinus, Jacobus; KARKARE, Radhika; MOORE, Michael, Douglas
Patent: WO2014/71122 A1, 2014 ;
反应条件
1: 25 percent / diphenyl ether 2: 99 percent / NaOH / H2O 3: 62 percent / POCl3 / diphenyl ether View Scheme
参考文献
Nanasawa; Tomoda; Hirai
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000 , vol. 344, p. 163 - 168
