[(1S,2S)-3-氯-2-羟基-1-甲基丙基]-, 1,1-二甲基乙酯 (9CI)合成路线 （共 5 条）
反应条件
potassium hydroxide in ethanol T=20°C;
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
1: n-tetradecylmagnesium chloride With copper(l) iodide in tetrahydrofuran
T=0°C; Inert atmosphere;
2: (S)-1-lt;(S)-1-(tert-butoxycarbonylamino)ethylgt;oxirane in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Allepuz, Ana C.; Badorrey, Ramon; Diaz-de-Viliegas, Maria D.; Galvez, Jose A.
European Journal of Organic Chemistry, 2009 , # 35 p. 6172 - 6178
反应条件
1: n-tetradecylmagnesium chloride With copper (I) cyanide in tetrahydrofuran
T=0°C; Inert atmosphere;
2: (S)-1-lt;(S)-1-(tert-butoxycarbonylamino)ethylgt;oxirane in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Allepuz, Ana C.; Badorrey, Ramon; Diaz-de-Viliegas, Maria D.; Galvez, Jose A.
European Journal of Organic Chemistry, 2009 , # 35 p. 6172 - 6178
反应条件
sodium tetrahydroborate in ethanol; toluene
T=-78 - 20°C;
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
1: LDA / tetrahydrofuran / -90 °C
2: NaBH4 / toluene; ethanol / -78 - 20 °C
View Scheme
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
