6-硝基-4-(4-苯氧基苯基乙基氨基)喹唑啉合成路线 （共 4 条）
反应条件
triethylamine in isopropyl alcohol
T=20°C; 1 h;
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: SOCl2; DMF / 3 h / Heating
2: 403 mg / Et3N / propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: 89 percent / conc. HCl / 1.5 h / 20 °C
2: SOCl2; DMF / 3 h / Heating
3: 403 mg / Et3N / propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: 88 percent / HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 1 h / 20 °C
2: 89 percent / conc. HCl / 1.5 h / 20 °C
3: SOCl2; DMF / 3 h / Heating
4: 403 mg / Et3N / propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
