N-(2,3-环氧丙基)邻苯二甲酰胺合成路线 （共 23 条）
反应条件
[hydrido-tris(3,5-dimethylpyrazolyl)borate]ReO3; triphenylphosphine in benzene-d6
T=75 - 105°C; 394 h;
参考文献
Gable, Kevin P.; Brown, Eric C.
Synlett, 2003 , # 14 p. 2243 - 2245
反应条件
1: T=80°C; 3 h;
2: With sulfuric acid
T=150°C; 24 h;
3: With sodium hydroxide in water
pH=~ 12; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82862 A1, 2003 ;
Location in patent: Page/Page column 27 ;
WO 03/082862 A1
反应条件
1: 75.2 percent / BF3*Et2O / CH2Cl2 / 18 h / 40 °C
2: 1,8-bis(dimethylamino)naphthalene / CH2Cl2 / 78 h / Heating
View Scheme
参考文献
Heyes; Niculescu-Duvaz; Cooper; Springer
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 99 - 114
