6-(噻吩-2-基)-2,3-二氢吡嗪-3-酮合成路线 （共 6 条）
反应条件
sodium hydroxide; m-nitrobenzene sulfonic acid sodium salt in ethanol; water
T=100°C; 2 h;
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
sodium hydroxide in water; acetic acid
参考文献
American Cyanamid Company
Patent: US4260756 A1, 1981 ;
反应条件
1: 85 percent / N2H4*H2O / ethanol / 7 h / Heating
2: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
1: aq. N2H4 / Heating
2: 64 percent / SeO2 / various solvent(s) / Heating
View Scheme
参考文献
Powell, Paul; Sosabowski, Michael H.
Journal of Chemical Research, Miniprint, 1995 , # 10 p. 2422 - 2434
反应条件
hydrazine hydrate; acetic acid
1) 110 deg C, 2) water, reflux; Yield given. Multistep reaction;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C
2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
