5,6-二甲基-4-嘧啶胺合成路线 (共 6 条)
反应条件
1: With N-(diphenylmethylene)amine; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=80°C; 1 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/3997 A1, 2009 ;
Location in patent: Page/Page column 21 ;
WO 2009/003997 A1
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
反应条件
1: alcohol; ammonia / 100 °C / im Rohr
2: concentrated hydriodic acid; red phosphorus
View Scheme
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813