1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: ethyl 4-ethoxybenzoate in tetrahydrofuran; hexane T=-78°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water
hydrazine hydrate in ethanol 2 h; Heating; Yield given;
参考文献
Larsen, Scott D.; Spilman, Charles H.; Bell, Frank P.; Dinh, Dac M.; Martinborough, Esther; Wilson, Gracella J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1721 - 1727