2,8- 二氮杂螺[4,5]癸烷-1-酮合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: triethylamine / tetrahydrofuran; water 2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C 2.2: 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 90 °C 4.1: 10 Pd/C; hydrogen / ethanol 5.1: trifluoroacetic acid / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1: sodium azide / N,N-dimethyl-formamide / 90 °C 2: 10 Pd/C; hydrogen / ethanol 3: trifluoroacetic acid / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C 1.2: 20 °C 2.1: sodium azide / N,N-dimethyl-formamide / 90 °C 3.1: 10 Pd/C; hydrogen / ethanol 4.1: trifluoroacetic acid / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1: 10 Pd/C; hydrogen / ethanol 2: trifluoroacetic acid / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 22 p. 6876 - 6881,6
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -65 °C / |Inert atmosphere 1.2: -65 - 20 °C / |Inert atmosphere 2.1: ammonium hydroxide; hydrogen / methanol / 18 h / 50 °C / 15001.5 Torr 3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme
