4-氯-6,7-二氢-5H-环戊并嘧啶-2-胺合成路线 （共 10 条）
反应条件
ethanol; ammonia T=150°C;
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
反应条件
palladium on activated charcoal; ethanol Hydrogenation.unter Zusatz von MgO;
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
反应条件
N,N-dimethyl-aniline; trichlorophosphate
T=135 - 140°C; 1 h;
参考文献
Ohno; Mizukoshi; Komatsu; Kunoh; Nakamura; Katoh; Nagasaka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4150 - 4165
反应条件
1: ethanol
2: POCl3
View Scheme
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
反应条件
1: potassium tert-butylate / tert-butyl alcohol / |Reflux
2: trichlorophosphate / 3 h / |Reflux
View Scheme
参考文献
Gangjee, Aleem; Zhao, Ying; Raghavan, Sudhir; Rohena, Cristina C.; Mooberry, Susan L.; Hamel, Ernest
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6829 - 6844
反应条件
1: ethanol
2: water; methanol; NaOH
View Scheme
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
反应条件
in methanol; xylene
3 h; Heating / reflux;
参考文献
Wyeth
Patent: US2006/276446 A1, 2006 ;
Location in patent: Page/Page column 28 ;
US 20060276446 A1
反应条件
in xylene
3 h; Heating / reflux;
参考文献
WYETH
Patent: WO2003/93280 A1, 2003 ;
Location in patent: Page/Page column 148 ;
反应条件
methanol; sodium methylate; xylene
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
Full Text Show Details
Braker et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 3072,3075
反应条件
methanol; diethylene glycol dimethyl ether
参考文献
Ross et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111
