2-溴-N,N-二甲基苯甲酰胺合成路线 （共 12 条）
反应条件
N-bromosuccinmide; silver hexafluoroantimonate; [{(η5-C5Me5)RhCl}2(μ-Cl)2]; 2,2,2-trimethylacetic acid in 1,2-dichloro-ethane T=70°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Schroeder, Nils; Wencel-Delord, Joanna; Glorius, Frank
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8298 - 8301
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; Oxidation; substitution;
参考文献
Journal of Organic Chemistry, , vol. 65, # 20 p. 6398 - 6411
反应条件
hydrogenchloride; tert.-butylhydroperoxide; iodine in cyclohexane; water T=70 - 80°C; 20 h;
参考文献
Gao, Lingfeng; Tang, Haoming; Wang, Zhiyong
Chemical Communications, 2014 , vol. 50, # 31 p. 4085 - 4088
反应条件
tert.-butylhydroperoxide; iodine; sodium hydroxide T=70 - 80°C; 24 h;
参考文献
Xu, Kun; Hu, Yanbin; Zhang, Sheng; Zha, Zhenggen; Wang, Zhiyong
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9793 - 9797
参考文献
Polish Journal of Chemistry, , vol. 57, # 4/5/6 p. 429 - 434
反应条件
1: 87 percent / acetonitrile; H2O / 48 h / 20 °C 2: 62 percent / NaH / dimethylformamide / 0 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 20 p. 6398 - 6411
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: N-bromosuccinmide; silver hexafluoroantimonate; [{(η5-C5Me5)RhCl}2(μ-Cl)2]; 2,2,2-trimethylacetic acid / 1,2-dichloro-ethane / 24 h / 70 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 20 p. 8298 - 8301
反应条件
1: 91 percent / NaOtBu / Pd(OAc)2; rac-BINAP / toluene 2: 82 percent / NaH / dimethylformamide 3: 70 percent / LDA; TMEDA; n-BuLi / tetrahydrofuran; hexane / 1 h / -20 °C 4: 70 percent / Rh(PPh3)3Cl 5: 80 percent View Scheme
参考文献
Lohse, Olivier; Beutler, Ulrich; Fuenfschilling, Peter; Furet, Pascal; France, Julien; Kaufmann, Daniel; Penn, Gerhard; Zaugg, Werner
Tetrahedron Letters, 2001 , vol. 42, # 3 p. 385 - 389
反应条件
1: Pd0/Na2CO3 / 1,2-dimethoxy-ethane / Heating 2: 63 percent / TFA / 4 h / Heating View Scheme
参考文献
Siddiqui, M.A.; Snieckus, V.
Tetrahedron Letters, 1988 , vol. 29, # 43 p. 5463 - 5466
反应条件
2: 50 percent / MeLi / tetrahydrofuran / 8 h / -78 - 25 °C View Scheme
参考文献
Sibi, M.P.; Dankwardt, J.W.; Snieckus, V.
Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 271 - 273
