1-氨基-4-恶环己烷羧酸乙烯合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C; 13 h;
参考文献
Satoh, Tsuyoshi; Hirano, Mizue; Kuroiwa, Akio; Kaneko, Youhei
Tetrahedron, 2006 , vol. 62, # 39 p. 9268 - 9279
反应条件
1: 9,12-dioxa-1,3-diaza-dispiro[4.2.4.2]tetradecane-2,4-dione With barium dihydroxide in water T=150°C; 6 h; in an autoclave; 2: (NH4)2CO3 in water T=60°C; 1 h;
参考文献
US2003/232873 A1, ;
Page 13 ;
US 20030232873 A1
反应条件
1: With sodium hydroxide 96 h; Inert atmosphereReflux; 2: With hydrogenchloride in water T=0°C; pH=6;
参考文献
Zhao, Jinhao; Zhang, Jiangong; Xu, Bingrong; Wang, Zongcheng; Cheng, Jingli; Zhu, Guonian
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 19 p. 4779 - 4787
反应条件
1.1: potassium cyanide / ethanol; water / 8 h / 55 - 60 °C 1.2: 0 °C 2.1: sodium hydroxide / 96 h / Inert atmosphere; Reflux 2.2: 0 °C / pH 6 View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 60, # 19 p. 4779 - 4787
反应条件
1: 79.0 g / NaOH; Et3N / acetonitrile; H2O / 20 °C / pH 9 2: 68.7 g / aq. HCl / acetone / 4 h / 20 °C View Scheme
参考文献
Koppitz, Marcus; Reinhardt, Gabriele; Van Lingen, Anneke
Tetrahedron Letters, 2005 , vol. 46, # 6 p. 911 - 914
反应条件
1: 8-amino-1,4-dioxaspiro[4,5]decane-8-carboxylic acid With hydrogenchloride in water
pH=10;
2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione in water; acetonitrile
T=20°C;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
Location in patent: Page/Page column 109-110 ;
WO 2012/119941 A1
