4-(1,4-二噁螺[4.5]-7-癸烯-8-基)吗啉合成路线 （共 2 条）
反应条件
1: 1.) S8 / 1.) MeOH, 15 min, RT, 2.) MeOH, 17 h 2: 80 percent / t-butylnitrite, CuCl2 / acetonitrile / 1.5 h, RT; 65 deg C, 2.5 h 3: 66 percent / 5percent aq. HCl / dioxane / 18 h / 90 °C View Scheme
参考文献
Kozikowski; Tuckmantel; Saxena; Doctor
Helvetica Chimica Acta, 1994 , vol. 77, # 5 p. 1256 - 1266
反应条件
toluene-4-sulfonic acid in toluene
T=132°C; 12 h; Dean-Stark apparatus;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; HICKEN, Erik James; HUNT, Kevin W.; RODRIGUEZ, Martha E.; TANG, Tony P.; SIU, Michael
Patent: WO2013/148851 A1, 2013 ;
Location in patent: Paragraph 0096 ;
