8-氨基-1H-苯并吡喃并[3,2-b]吡啶-6(7H)-酮合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=3102.9 Torr;
参考文献
Villani,F.J. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 1 - 8
反应条件
1: polyphosphoric acid / 16 h / 100 - 120 °C
2: KNO3, H2SO4 / -5 - 0 °C
3: H2 / Pd-C / ethanol / 3102.9 Torr
View Scheme
参考文献
Villani,F.J. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 1 - 8
反应条件
1: KNO3, H2SO4 / -5 - 0 °C
2: H2 / Pd-C / ethanol / 3102.9 Torr
View Scheme
参考文献
Villani,F.J. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 1 - 8
反应条件
hydrogen bromide; phenol
Deacetylation; 2 h; Heating;
参考文献
Fujiwara, Hidetoshi; Kitagawa, Kouki
Heterocycles, 2000 , vol. 53, # 2 p. 409 - 417
反应条件
1: 74 percent / K2CO3; Cu; CuI / dimethylformamide / 2 h / Heating
2: 76 percent / PPA / 8 h / 130 °C
3: 89 percent / conc. HBr; phenol / 2 h / Heating
View Scheme
参考文献
Fujiwara, Hidetoshi; Kitagawa, Kouki
Heterocycles, 2000 , vol. 53, # 2 p. 409 - 417
反应条件
1: 74 percent / K2CO3; Cu; CuI / dimethylformamide / 2 h / Heating
2: 76 percent / PPA / 8 h / 130 °C
3: 89 percent / conc. HBr; phenol / 2 h / Heating
View Scheme
参考文献
Fujiwara, Hidetoshi; Kitagawa, Kouki
Heterocycles, 2000 , vol. 53, # 2 p. 409 - 417
反应条件
sulfuric acid; hydroxylammonium sulfate; iron(II) sulfate
T=140 - 150°C; amination; 7 h;
参考文献
Fujiwara, Hidetoshi; Kitagawa, Kouki
Heterocycles, 2000 , vol. 53, # 2 p. 409 - 417
反应条件
1: 76 percent / PPA / 8 h / 130 °C
2: 89 percent / conc. HBr; phenol / 2 h / Heating
View Scheme
参考文献
Fujiwara, Hidetoshi; Kitagawa, Kouki
Heterocycles, 2000 , vol. 53, # 2 p. 409 - 417
