1-(2-羟乙基)-4-甲基哌嗪合成路线 （共 16 条）
反应条件
sodium anschl. mit <1-Chlor-cyclohexyl>-cyclohexyl-keton auf 100grad;
参考文献
Verrier
Bulletin de la Societe Chimique de France, 1959 , p. 1863
参考文献
Lespagnol; Cuingnet
9. Congr. Soc. Pharm. Clermont-Ferrand, 1957 , p. 175,178
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane
T=0 - 20°C;
参考文献
Hangauer, David G.
Patent: US2006/160800 A1, 2006 ;
Location in patent: Page/Page column 85-86 ;
US 20060160800 A1
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C; Mitsunobu reaction; 18 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2004/7498 A2, 2004 ;
Location in patent: Page 30 ;
WO 2004/007498 A2
反应条件
1: 69.1 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
in chlorobenzene
Heating;
参考文献
Schuler,W.A. et al.
Justus Liebigs Annalen der Chemie, 1964 , vol. 673, p. 102 - 112
