1-(2-甲氧基苯基)哌嗪盐酸盐合成路线 （共 16 条）
反应条件
1: 98 percent / K2CO3 / acetonitrile / 14 h / Heating
2: 91 percent / hydrazine hydrate / methanol / 2 h / Heating
View Scheme
参考文献
Hackling, Anneke; Ghosh, Robin; Perachon, Sylvie; Mann, Andre; Hoeltje, Hans-Dieter; Wermuth, Camille G.; Schwartz, Jean-Charles; Sippl, Wolfgang; Sokoloff, Pierre; Stark, Holger
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3883 - 3899
反应条件
in 1-chloro-3-[4-(2-methoxyphenyl)-piperazin-1-yl]propane
参考文献
HELTON, David; FICK, David
Patent: US2009/264443 A1, 2009 ;
反应条件
triethylamine in chloroform
Ambient temperature;
参考文献
Shiozawa; Ichikawa; Komuro; Ishikawa; Furuta; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 3981 - 3993
反应条件
sodium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide
参考文献
HELTON, David; FICK, David
Patent: US2009/264443 A1, 2009 ;
反应条件
1: 99 percent / K2CO3; KI; DMF / acetonitrile / Heating
2: 81 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Bolzati, Cristina; Salvarese, Nicola; Carta, Davide; Refosco, Fiorenzo; Dolmella, Alessandro; Pietzsch, Hans Juergen; Bergmann, Ralf; Bandoli, Giuliano
Journal of Biological Inorganic Chemistry, 2011 , vol. 16, # 1 p. 137 - 155
反应条件
potassium carbonate in acetonitrile
48 h; Reflux;
参考文献
Hazari, Puja Panwar; Schulz, Jurgen; Vimont, Delphine; Chadha, Nidhi; Allard, Michele; Szlosek-Pinaud, Magali; Fouquet, Eric; Mishra, Anil Kumar
ChemMedChem, 2014 , vol. 9, # 2 p. 337 - 349
