5-乙氧基-2-苯基-1,3-恶唑-4-羧酸合成路线 (共 18 条)
反应条件
1: 86 percent / oxalyl chloride, DMF / CH2Cl2; diethyl ether / 2 h / Ambient temperature 2: 72 percent / aq. NaOH / CH2Cl2 / 3 h / Ambient temperature 3: 75 percent / toluene / 1.5 h / Heating 4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H2O View Scheme
参考文献
Turchi, Ignatius J.; Maryanoff, Cynthia A.
Synthesis, 1983 , # 10 p. 837 - 839
反应条件
1: 86 percent / oxalyl chloride, DMF / CH2Cl2; diethyl ether / 2 h / Ambient temperature 2: 78 percent / aq. NaOH / CH2Cl2 / 3 h / Ambient temperature 3: 84 percent / toluene / 1.5 h / Heating 4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H2O View Scheme
参考文献
Turchi, Ignatius J.; Maryanoff, Cynthia A.
Synthesis, 1983 , # 10 p. 837 - 839
反应条件
potassium hydroxide in water
T=100°C; 0.5 h;
参考文献
Nolt, M. Brad; Smiley, Mark A.; Varga, Sandor L.; McClain, Ray T.; Wolkenberg, Scott E.; Lindsley, Craig W.
Tetrahedron, 2006 , vol. 62, # 19 p. 4698 - 4704
反应条件
1: 94 percent / ethyldiisopropylamine
2: 79 percent / trifluoroacetic anhydride / various solvent(s) / 0.17 h / 160 °C / microwave irradiation
3: 48 percent / potassium hydroxide / H2O / 0.5 h / 100 °C
View Scheme
参考文献
Nolt, M. Brad; Smiley, Mark A.; Varga, Sandor L.; McClain, Ray T.; Wolkenberg, Scott E.; Lindsley, Craig W.
Tetrahedron, 2006 , vol. 62, # 19 p. 4698 - 4704
反应条件
1: 79 percent / trifluoroacetic anhydride / various solvent(s) / 0.17 h / 160 °C / microwave irradiation
2: 48 percent / potassium hydroxide / H2O / 0.5 h / 100 °C
View Scheme
参考文献
Nolt, M. Brad; Smiley, Mark A.; Varga, Sandor L.; McClain, Ray T.; Wolkenberg, Scott E.; Lindsley, Craig W.
Tetrahedron, 2006 , vol. 62, # 19 p. 4698 - 4704
反应条件
1: 94 percent / ethyldiisopropylamine
2: 79 percent / trifluoroacetic anhydride / various solvent(s) / 0.17 h / 160 °C / microwave irradiation
3: 48 percent / potassium hydroxide / H2O / 0.5 h / 100 °C
View Scheme
参考文献
Nolt, M. Brad; Smiley, Mark A.; Varga, Sandor L.; McClain, Ray T.; Wolkenberg, Scott E.; Lindsley, Craig W.
Tetrahedron, 2006 , vol. 62, # 19 p. 4698 - 4704
参考文献
Cornforth
Chem. Penicillin, <Princeton 1949>, S. 688, 723
反应条件
1: 86 percent / oxalyl chloride, DMF / CH2Cl2; diethyl ether / 2 h / Ambient temperature
2: 88 percent / aq. NaOH / CH2Cl2 / 3 h / Ambient temperature
3: 92 percent / toluene / 1.5 h / Heating
4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H2O
View Scheme
参考文献
Turchi, Ignatius J.; Maryanoff, Cynthia A.
Synthesis, 1983 , # 10 p. 837 - 839
反应条件
1: 86 percent / oxalyl chloride, DMF / CH2Cl2; diethyl ether / 2 h / Ambient temperature
2: 91 percent / aq. NaOH / CH2Cl2 / 3 h / Ambient temperature
3: 90 percent / toluene / 4 h / Heating
4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H2O
View Scheme
参考文献
Turchi, Ignatius J.; Maryanoff, Cynthia A.
Synthesis, 1983 , # 10 p. 837 - 839
反应条件
1: 86 percent / oxalyl chloride, DMF / CH2Cl2; diethyl ether / 2 h / Ambient temperature
2: 89 percent / aq. NaOH / CH2Cl2 / 3 h / Ambient temperature
3: 93 percent / toluene / 1.5 h / Heating
4: 1.) KOH; 2.) AcOH / 1.) EtOH, room temp., 8 h; 2.) H2O
View Scheme
参考文献
Turchi, Ignatius J.; Maryanoff, Cynthia A.
Synthesis, 1983 , # 10 p. 837 - 839