2-氨基-5-甲基-3-硝基苯甲酸合成路线 （共 6 条）
反应条件
ethanol; copper Diazotization.zuletzt bei Siedetemperatur;
参考文献
Adams; Snyder
Journal of the American Chemical Society, 1938 , vol. 60, p. 1411,1413
反应条件
in methanol; diethyl ether
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 78-79 ;
WO 2010/115736 A2
反应条件
1: With dihydrogen peroxide; sodium hydroxide in water
T=20°C; 12.05 h;
2: With hydrogenchloride in water
pH=2;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 78 ;
WO 2010/115736 A2
反应条件
sodium hydroxide in water
3 h; Heating;
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 70 percent / tetrahydrofuran / 12 h / 20 °C
2: 87 percent / fuming HNO3 / 1 h / 4 °C
3: 92 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 87 percent / fuming HNO3 / 1 h / 4 °C
2: 92 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
