1-[4-(戊基氧基)苯基]乙酮合成路线 （共 10 条）
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 2: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C View Scheme
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Tsuboi, Hiroyuki; Hashimoto, Norio
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 179 - 184
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 2: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C 3: water; potassium carbonate / tetrahydrofuran; methanol / 2 h / 50 - 60 °C / |Large scale 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / 4 h / 20 - 30 °C / |Large scale View Scheme
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Tsuboi, Hiroyuki; Hashimoto, Norio
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 179 - 184
反应条件
1: 83 percent / HNO3, H2SO4 / 2 h / -8 - -5 °C 2: 30 percent / ethanol / 5 h View Scheme
参考文献
Iradyan, M. A.; Iradyan, N. S.; Stepanyan, G. M.; Arsenyan, F. G.; Garibdzhanyan, B. T.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 2 p. 92 - 96
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 2 p. 22 - 24
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 2: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 179 - 184
反应条件
potassium carbonate in water; ethyl acetate; acetone
参考文献
Eastman Kodak Company
Patent: US6197071 B1, 2001 ;
反应条件
1.1: copper(l) iodide; 8-Hydroxyquinoline 1-oxide / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere
1.2: 28 h / 100 °C / Inert atmosphere
2.1: cesium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide / water; dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Yang, Kai; Li, Zheng; Wang, Zhaoyang; Yao, Zhiyi; Jiang, Sheng
Organic Letters, 2011 , vol. 13, # 16 p. 4340 - 4343
反应条件
1.1: copper(l) iodide; 8-Hydroxyquinoline 1-oxide / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere
1.2: 24 h / 110 °C / Inert atmosphere
2.1: cesium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide / water; dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Yang, Kai; Li, Zheng; Wang, Zhaoyang; Yao, Zhiyi; Jiang, Sheng
Organic Letters, 2011 , vol. 13, # 16 p. 4340 - 4343
反应条件
1: AlCl3; CS2
2: methanol. NaOH
View Scheme
参考文献
McCoubrey; Iyengar
Journal of the Chemical Society, 1951 , p. 3430,3432
参考文献
Profft
Arzneimittel Forschung, 1958 , vol. 8, p. 268
反应条件
in methanol; hexane; dichloromethane
参考文献
Boyce, Rustum S.; Cherian, Joseph; Calanasan, Cleofe; Sihombing, Muhammad Sofian Asi
Patent: US2011/224129 A1, 2011 ;
