2-甲氧基-5-硝基-6-甲基吡啶合成路线 （共 15 条）
反应条件
sulfuric acid; nitric acid in water T=20 - 80°C;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED
Patent: WO2004/62665 A1, 2004 ;
Location in patent: Page/Page column 44-45 ;
WO 2004/062665 A1
反应条件
1: 2-chloro-6-methoxy-3-nitro-pyridine With tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water 0.25 h; 2: trimethylboroxine With potassium carbonate in 1,4-dioxane; water T=20°C; 22 h; Heating / reflux;
参考文献
WO2004/104001 A2, ;
Page 43 ;
WO 2004/104001 A2
反应条件
1: With sodium T=0°C; 4 h; 2: With acetic acid
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 23 ;
参考文献
US6358972 B1, ;
US 6358972 B1
参考文献
WO2009/155156 A1, ;
Page/Page column 74-75 ;
WO 2009/155156 A1
反应条件
1: phosphorus (V)-chloride; phosphoryl chloride 2: methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3828,3830
反应条件
1: aqueous sodium nitrite; aqueous sulfuric acid / Diazotization 2: phosphorus (V)-chloride; phosphoryl chloride 3: methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3828,3830
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3828,3830
反应条件
hydrogenchloride; water Reflux;
参考文献
Hartz, Richard A.; Ahuja, Vijay T.; Schmitz, William D.; Molski, Thaddeus F.; Mattson, Gail K.; Lodge, Nicholas J.; Bronson, Joanne J.; Macor, John E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1890 - 1894
反应条件
iron; ammonium chloride in methanol; water T=80°C; 16 h;
参考文献
WO2004/62665 A1, ;
Page/Page column 45 ;
WO 2004/062665 A1
