反应条件
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere 2: ammonium acetate / anhydrous xylene / 3 h / 140 °C / |Sealed tube; |Inert atmosphere View Scheme
参考文献
Belema, Makonen; Nguyen, Van N.; Romine, Jeffrey L.; St. Laurent, Denis R.; Lopez, Omar D.; Goodrich, Jason T.; Nower, Peter T.; O'Boyle, Donald R.; Lemm, Julie A.; Fridell, Robert A.; Gao, Min; Fang, Hua; Krause, Rudolph G.; Wang, Ying-Kai; Oliver, A. Jayne; Good, Andrew C.; Knipe, Jay O.; Meanwell, Nicholas A.; Snyder, Lawrence B.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1995 - 2012