alpha,alpha-二(4-甲基苯基)-吡啶-2-基-甲醇合成路线 （共 2 条）
反应条件
1: para-bromotoluene With iodine; magnesium in tetrahydrofuran
3 h; RefluxInert atmosphere;
2: 2-Pyridinecarboxylic acid methyl ester in tetrahydrofuran
T=0 - 20°C; Grignard reaction; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran
参考文献
Shi, Bing-Feng; Maugel, Nathan; Zhang, Yang-Hui; Yu, Jin-Quan
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4882 - 4886
参考文献
McCarty et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 472,476
