5-溴-1,2,4-三甲基苯合成路线 （共 32 条）
参考文献
Chemische Berichte, , vol. 33, p. 2535
参考文献
Chemische Berichte, , vol. 19, p. 1551
参考文献
Journal of the Indian Chemical Society, , vol. 11, p. 351
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C 2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr 3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h 4: 98 percent / NaH / dimethylsulfoxide / 10 h 5: 72 percent / phosphorus oxychloride / 24 h / 70 °C View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
参考文献
Jannasch
Chemische Berichte, 1874 , vol. 7, p. 692
Full Text Show Details
Jannasch; Fittig
Zeitschrift fuer Chemie, 1870 , p. 161
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C 2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr 3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
carbon dioxide in tetrahydrofuran
参考文献
AstraZeneca U.K. Limited
Patent: US6162808 A1, 2000 ;
US 6162808 A
参考文献
Barcon, Alan; Cote, Marie L.; Brunskill, Andrew P. J.; Thompson, Hugh W.; Lalancette, Roger A.
Acta Crystallographica Section C: Crystal Structure Communications, 1997 , vol. 53, # 12 p. 1842 - 1845
参考文献
Mannschreck, Albrecht; Hartmann, Erwin; Buchner, Hans; Andert, Doris
Tetrahedron Letters, 1987 , vol. 28, # 30 p. 3479 - 3482
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C 2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr 3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h 4: 98 percent / NaH / dimethylsulfoxide / 10 h View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
