5-溴-1,2,4-三甲基苯合成路线 （共 32 条）
反应条件
1: 90.7 percent / conc. H2SO4, 98percent aq. HNO3 / CHCl3 / 2 h / 0 °C
2: 75.5 percent / NaOH, H2 / Raney Ni / ethanol / 114000 Torr
3: 1.) 25percent aq, H2SO4, aq. NaNO2, 2.) 20percent aq. H2SO4 / 1.) 0 deg C, 1 h, 2.) reflux, 2 h
4: 98 percent / NaH / dimethylsulfoxide / 10 h
5: 72 percent / phosphorus oxychloride / 24 h / 70 °C
6: 87 percent / 10percent aq. NaOH / 6 h / Ambient temperature
View Scheme
参考文献
Makin, S. M.; Mikerin, I. E.; Dobretsova, E. K.; Shavrygina, O. A.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 4 p. 572 - 575
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 4 p. 682 - 686
反应条件
sulfuric acid
man spaltet die Sulfonsaeure mit Salzsaeure bei 180-190grad;
参考文献
Jacobsen
Chemische Berichte, 1889 , vol. 22, p. 1580
