1: 60 percent / β-methyl aspartase; KCl; NH4Cl / MgCl2*6H2O / H2O / 32 °C / pH 9 2: tetrahydrofuran / 0 - 20 °C 3: 2 h / 20 °C 4: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 5: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 6: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

暂无反应条件数据

permanganate(VII) ion

暂无反应条件数据

ammonium hydroxide; 3-methylaspartate ammonia-lyase; sodium chloride; magnesium chloride T=30°C; 50 h;

1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene Heating; 2: With hydrogenchloride 3 h; Heating;

sodium hydroxide; bromine

zinc der Aethylester entsteht;

potassium hydroxide; sodium hydride 1.) diethyl ether, -78 deg C, 3 h then room temperature, 2.) ethanol-water 1 : 1, reflux; Yield given. Multistep reaction. Yields of byproduct given;

in water T=20°C; Michaelis and catalytic center activity constants for deamination reaction by 3-methylaspartase from Morganella morganii strain YG-0601; pH 9.7;