1: bromoacetaldehyde dimethylacetal With hydrogen bromide in water T=120°C; 0.5 h; Inert atmosphere; 2: 3-amino-6-chloro-pyridazine With sodium hydrogencarbonate in ethanol; water T=0 - 80°C; Inert atmosphere;
1: monobromoacetic acid With N-ethyl-N,N-diisopropylamine in methanol; water T=5 - 7°C; 3.5 h; 2: 3-amino-6-chloro-pyridazine in methanol; water T=50°C; 12.5 - 16 h; Product distribution / selectivity;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2007/26624 A1, 2007 ;
Location in patent: Page/Page column 7-8 ;
