反应条件
chloro-trimethyl-silane; zinc(II) chloride; lithium diisopropyl amide
1) THF, -78 deg C, 30 min, 2) -78 deg C to r.t., 3) CH2Cl2, 24 h; t-Alkylation of carboxylic esters via their ketene alkyl trimethylsilyl acetals by the Friedel-Crafts reaction allows the synthesis of highly hindered compounds.;
参考文献
Lion, Claude; Dubois, Jacques-Emile
Tetrahedron, 1981 , vol. 37, p. 319 - 323
