4-氯-2-吡啶甲酸合成路线

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Bristol-Myers Squibb Company; Vrudhula, Vivekananda M.; Pan, Senliang; Rajamani, Ramkumar; Macor, John E.; Bronson, Joanne J.; Dzierba, Carolyn Diane; Nara, Susheel Jethanand; Karatholuvhu, Maheswaran Sivasamban
Patent: US2013/237555 A1, 2013 ;

5470-22-44-氯-2-吡啶甲酸

2767-90-01-吡啶-4-哌啶

参考文献

Graf
Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 138, p. 244,257

67-56-1甲醇+

5470-22-44-氯-2-吡啶甲酸

24484-93-34-氯吡啶-2-甲酸甲酯

参考文献

F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; ZUBIETA, Chloe
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5470-22-44-氯-2-吡啶甲酸+

18107-18-1三甲基硅烷化重氮甲烷

24484-93-34-氯吡啶-2-甲酸甲酯

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THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED; LESSENE, Guillaume Laurent; BAELL, Jonathan Bayldon; BURGESS, Antony Wilks; MARUTA, Hiroshi
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WO 2012/003544 A1

5470-22-44-氯-2-吡啶甲酸+

74-88-4甲基碘

24484-93-34-氯吡啶-2-甲酸甲酯

参考文献

Boehringer Ingelheim Pharmaceuticals, Inc.
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5470-22-44-氯-2-吡啶甲酸

24484-93-34-氯吡啶-2-甲酸甲酯

参考文献

F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; JUNG, Laurence
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5470-22-44-氯-2-吡啶甲酸

66933-68-44-(4-吗啉)-甲酸吡啶

参考文献

WO2012/3544 A1, ;
WO 2012/003544 A1

5470-22-44-氯-2-吡啶甲酸+

64-17-5乙醇

71777-70-34-乙氧基-2-吡啶甲酸乙酯

参考文献

WO2007/16525 A2, ;

Page/Page column 54 ;
WO 2007/016525 A2

5470-22-44-氯-2-吡啶甲酸

63071-10-34-氯-2-吡啶甲醇

参考文献

Wiles, Jason A.; Song, Yongsheng; Wang, Qiuping; Lucien, Edlaine; Hashimoto, Akihiro; Cheng, Jijun; Marlor, Christopher W.; Ou, Yangsi; Podos, Steven D.; Thanassi, Jane A.; Thoma, Christy L.; Deshpande, Milind; Pucci, Michael J.; Bradbury, Barton J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1277 - 1281

5470-22-44-氯-2-吡啶甲酸+

64-17-5乙醇

64064-56-84-氯吡啶-2-甲酸乙酯

参考文献

Purandare, Ashok V.; Gao, Aiming; Wan, Honghe; Somerville, John; Burke, Christine; Seachord, Carrie; Vaccaro, Wayne; Wityak, John; Poss, Michael A.
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