反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 0 - 20 °C 2: 0.5 h / 20 °C 3: sodium azide / water; N,N-dimethyl-formamide / 48 h / 80 °C 4: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 3000.3 Torr View Scheme
参考文献
F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; ZUBIETA, Chloe
Patent: US2013/102600 A1, 2013 ;