2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
参考文献
Bojarska-Dahlig
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 981,983 Anm. 4
参考文献
Kubota; Akita
Yakugaku Zasshi, 1958 , vol. 78, p. 248
Chem.Abstr., 1958 , p. 11834
反应条件
1: in tetrahydrofuran T=-60°C; Inert atmosphere; 2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran T=-60 - 20°C; Inert atmosphere; regioselective reaction;
参考文献
Zhang, Fang; Duan, Xin-Fang
Organic Letters, 2011 , vol. 13, # 22 p. 6102 - 6105
反应条件
hydrogenchloride T=160°C; Erwaermen des Reaktionsprodukts mit Essigsaeure und Eisen-Pulver;
参考文献
Profft; Rolle
Wiss. Z.T.H. Leuna-Merseburg, 1959 , vol. 2, p. 187,190
反应条件
1: 85 percent / PCl3 / CHCl3 / 3 h / Ambient temperature 2: 61 percent / AcBr / 6 h / Heating 3: KMnO4 / H2O / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: NaOH-solution 2: zinc; sulfuric acid; water View Scheme
参考文献
Profft
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 429,434
反应条件
1: H2 / PtO2 / acetic acid / 2068.6 Torr 2: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 3: HNO3, H2SO4 / 2 h / Heating View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1.1: tetrahydrofuran / -60 °C / Inert atmosphere 1.2: -60 - 20 °C / Inert atmosphere 2.1: methanol / 60 °C 3.1: acetic anhydride / 110 °C 3.2: 2 h / 70 °C 4.1: manganese(IV) oxide / chloroform / 20 °C 5.1: pyridine; hydroxylamine hydrochloride / ethanol / Reflux View Scheme
参考文献
Zhang, Fang; Duan, Xin-Fang
Organic Letters, 2011 , vol. 13, # 22 p. 6102 - 6105
反应条件
1: H2 / PtO2 / acetic acid / 2068.6 Torr 2: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 3: HNO3, H2SO4 / 2 h / Heating 4: 26.7 g / POCl3 / 2 h / Heating View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1.1: dimethyl sulfate / 1 h / 70 °C 1.2: 50 percent / H2O / 0 - 20 °C 2.1: 90 percent sulfuric acid / H2O / 2 h / 120 °C 2.2: 91 percent / sodium nitrite / H2O / 2 h / 20 - 80 °C View Scheme
参考文献
Hoare, Jason L.; Cavell, Kingsley J.; Hecker, Richard; Skelton, Brian W.; White, Allan H.
Journal of the Chemical Society - Dalton Transactions, 1996 , # 11 p. 2197 - 2205
