2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Further byproducts given. Yields of byproduct given;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; other catalysts, other solvents, other temperatures, other pressures; Product distribution;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
1: NaOH-solution 2: zinc; sulfuric acid; water View Scheme
参考文献
Profft
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 429,434
反应条件
1: 0.5 h / 110 - 120 °C 2: 1 mol/l aq. NaOH / methanol / 0.75 h / 20 °C 3: SOCl2 / CH2Cl2 / Heating View Scheme
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
反应条件
trifluoroacetic anhydride in dichloromethane T=20°C; 72 h;
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
acetic anhydride Erwaermen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Furukawa
Yakugaku Zasshi, 1957 , vol. 77, p. 11,13
Chem.Abstr., 1957 , p. 8745
反应条件
T=110 - 120°C; und Erwaermen des Reaktionsprodukts mit wss. Salzssaeure;
参考文献
Furukawa
Yakugaku Zasshi, 1957 , vol. 77, p. 11,13
Chem.Abstr., 1957 , p. 8745
反应条件
1: acetic anhydride 2: thionyl chloride View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 77.6 percent / conc. aq. HCl / 10 h / 160 °C 2: 68.4 percent / 0.5 h / 110 - 120 °C 3: 69.2 percent / 1 mol/l aq. NaOH / methanol / 0.75 h / 20 °C View Scheme
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
