2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
反应条件
1: iron-powder; acetic acid; aqueous HgCl2 2: water; sodium nitrite; sulfuric acid / und Erwaermen der Reaktoinsloesung 3: K2CO3 / 190 - 200 °C / 33097.9 - 47808 Torr View Scheme
参考文献
Bojarska-Dahlig; Gruda
Roczniki Chemii, 1957 , vol. 31, p. 1147,1151
Chem.Abstr., 1958 , p. 10072
反应条件
acetic anhydride; sodium hydrogencarbonate in ethanol; water
参考文献
KABUSHIKI KAISHA NARD KENKYUSHO
Patent: EP1455189 A1, 2004 ;
参考文献
Chen, Hongfeng; Sweet, James A.; Lam, Kin-Chung; Rheingold, Arnold L.; McGrath, Dominic V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 14 p. 1672 - 1682
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Further byproducts given. Yields of byproduct given;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
palladium on activated charcoal; water Hydrogenation;
参考文献
Ochiai; Suzuki
Yakugaku Zasshi, 1947 , vol. 67, p. 158
Chem.Abstr., 1951 , p. 9541
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; other catalysts, other solvents, other temperatures, other pressures; Product distribution;
参考文献
Ovchinnikov, V. G.; Litvinenko, G. S.; Maksimenko, N. M.; Sherstyuk, A. I.; Levkov, V. A.
J. Appl. Chem. USSR (Engl. Transl.), 1989 , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
参考文献
Kato et al.
Pharmaceutical Bulletin, 1956 , vol. 4, p. 178,181
参考文献
Bojarska-Dahlig
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 981,983 Anm. 4
