2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
参考文献
Kubota; Akita
Yakugaku Zasshi, 1958 , vol. 78, p. 248
Chem.Abstr., 1958 , p. 11834
反应条件
chloroformic acid ethyl ester in 1,2-dichloro-ethane T=25 - 40°C;
参考文献
Veerareddy, Arava; Surendrareddy, Gogireddy; Dubey
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 961 - 964
反应条件
1.1: hydrogenchloride / water / 72 h / Reflux 2.1: dichloromethane / 0.25 h 2.2: 96.33 h View Scheme
参考文献
VANDERBILT UNIVERSITY; CONN, P., Jeffrey; LINDSLEY, Craig, W.; EMMITTE, Kyle, A.; RODRIGUEZ, Alice, L.; FELTS, Andrew, S.; JONES, Carrie, K.; BATES, Brittney, S.; CHAUDER, Brian, A.
Patent: WO2012/118563 A2, 2012 ;
WO 2012/118563 A2
反应条件
methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; triphenylphosphine in benzene T=20°C; 5 h;
参考文献
Wang, Ying; Espenson, James H.
Organic Letters, 2000 , vol. 2, # 22 p. 3525 - 3526
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
反应条件
1: 85 percent / PCl3 / CHCl3 / 3 h / Ambient temperature 2: 61 percent / AcBr / 6 h / Heating 3: KMnO4 / H2O / Heating 4: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 5: 69 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
1: aq. HCl 2: aq. HCl View Scheme
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
反应条件
1: 85 percent / PCl3 / CHCl3 / 3 h / Ambient temperature 2: 61 percent / AcBr / 6 h / Heating 3: KMnO4 / H2O / Heating 4: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Hubrich, Michael; Peukert, Max; Seichter, Wilhelm; Weber, Edwin
Polyhedron, 2010 , vol. 29, # 7 p. 1854 - 1862
反应条件
1: NaOH-solution 2: zinc; sulfuric acid; water 3: water; acetic acid / 200 °C 4: potassium hydroxide View Scheme
参考文献
Profft
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 429,434
反应条件
1: 21.9 percent / 0.33 h / 110 - 120 °C 2: 92.4 percent / 10percent aq. HCl / 1 h / 70 - 80 °C 3: 2.51 g / MnO2 / CHCl3 / 48 h / Heating View Scheme
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
