2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
反应条件
1: 30 percent / Heating 2: 1) p-TsOH*H2O / 1) MeOH, reflux, 4 h, 2) Et2O, 1 h, 0 deg C 3: 57 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
1: trifluoroacetic anhydride / dichloromethane / 72 h / 20 °C 2: ethanol / 24 h / |Reflux 3: selenium(IV) oxide / 1,4-dioxane / 4 h / 90 °C View Scheme
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
1: 79.1 percent / methanol / 1.5 h / 20 °C 2: 0.5 h / 110 - 120 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: chloroform; phosphorus (III)-chloride 3: 180 °C View Scheme
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
反应条件
1: 2-methyl-4-nitropyridine 1-oxide With dimethyl sulfate T=70°C; 1 h; 2: potassium cyanide in water T=0 - 20°C; Reissert-Kaufmann reaction;
参考文献
Guery, Sebastien; Rival, Yveline; Wermuth, Camille G.
Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719
反应条件
dimethyl sulfate in hexane; water; ethyl acetate
参考文献
Kureha Kagaku Kogyo K.K.
Patent: US6610853 B1, 2003 ;
反应条件
1: 10.3 g / iron filings / acetic acid / 3 h / 66.9 °C 2: 7.2 g / H2SO4, NaNO2 / H2O / 91.9 °C View Scheme
参考文献
Bojarska-Dahlig; Gruda
Roczniki Chemii, 1957 , vol. 31, p. 1147,1151
Chem.Abstr., 1958 , p. 10072
反应条件
1: acetic anhydride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 17 p. 5186 - 5192
反应条件
1: 85 percent / PCl3 / CHCl3 / 3 h / Ambient temperature 2: 61 percent / AcBr / 6 h / Heating View Scheme
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
反应条件
iron; acetic acid T=70°C; 3 h;
参考文献
WO2004/14913 A2, ;
Page 81 ;
WO 2004/014913 A2
