2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Further byproducts given. Yields of byproduct given;
参考文献
J. Appl. Chem. USSR (Engl. Transl.), , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
J. Appl. Chem. USSR (Engl. Transl.), , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
反应条件
hydrogen; nickel on kieselguhr in methanol T=120°C; P=98800.1 Torr; 0.5 h; other catalysts, other solvents, other temperatures, other pressures; Product distribution;
参考文献
J. Appl. Chem. USSR (Engl. Transl.), , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468
参考文献
Yakugaku Zasshi, , vol. 78, p. 248
Chem.Abstr., , p. 11834
反应条件
1.1: dimethyl sulfate / 1 h / 70 °C 1.2: 50 percent / H2O / 0 - 20 °C 2.1: 90 percent sulfuric acid / H2O / 2 h / 120 °C 2.2: 91 percent / sodium nitrite / H2O / 2 h / 20 - 80 °C 3.1: 80 percent / 37 percent hydrochloric acid / 2 h / 100 °C View Scheme
参考文献
Guery, Sebastien; Rival, Yveline; Wermuth, Camille G.
Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719
反应条件
1: H2 / PtO2 / acetic acid / 2068.6 Torr 2: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 3: HNO3, H2SO4 / 2 h / Heating 4: 26.7 g / POCl3 / 2 h / Heating 5: N2H4*H2O / ethanol / 1.) 0 deg C, 0.75 h, 2.) 25 deg C, 3.5 h 6: H2 / 5percent Pd/C / aq. ethanol 7: conc. HCl / 2.5 h 8: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
1: H2 / PtO2 / acetic acid / 2068.6 Torr 2: 40 percent / HNO3, NaNO2 / H2O / <20 deg C 3: HNO3, H2SO4 / 2 h / Heating 4: 26.7 g / POCl3 / 2 h / Heating 5: ethanol / 5 h / Heating 6: H2, HCl / 5percent Pd/C / aq. ethanol / 2327.2 Torr 7: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h 8: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
acetyl-bromide; acetic acid
T=55 - 120°C;
参考文献
Jones, Roderick C.; Canty, Allan J.; Deverell, Jeremy A.; Gardiner, Michael G.; Guijt, Rosanne M.; Rodemann, Thomas; Smith, Jason A.; Tolhurst, Vicki-Anne
Tetrahedron, 2009 , vol. 65, # 36 p. 7474 - 7481
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
Patent: EP767172 A1, 1997 ;
反应条件
hydrogenchloride
T=160°C; 10 h;
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
