2-甲基-4-硝基吡啶-N-氧化物合成路线 （共 79 条）
反应条件
in dichloromethane; ethyl acetate; acetyl chloride
参考文献
Hoechst Aketiengesellschaft
Patent: US5114955 A1, 1992 ;
参考文献
Eisai Co., Ltd.
Patent: US5045552 A1, 1991 ;
US 5045552 A
反应条件
potassium carbonate
12 h; Heating;
参考文献
Chen, Hongfeng; Sweet, James A.; Lam, Kin-Chung; Rheingold, Arnold L.; McGrath, Dominic V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 14 p. 1672 - 1682
参考文献
Pfizer Inc.
Patent: US4562197 A1, 1985 ;
反应条件
in methanol
3 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/56886 A1, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/056886 A1
反应条件
1: chloroform; phosphorus (III)-chloride
3: 180 °C
4: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation
View Scheme
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 147
反应条件
1: NaOMe / 16 h / 40 °C
2: 2 h / 90 °C
3: 2 N aq. NaOH / 2 h / 80 °C
4: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
5: 2 N aq. NaOH / ethanol / 2 h / 50 °C
6: 94 percent / 10percent aq. NaOCl, 6 N aq. NaOH / ethyl acetate / 0.5 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 100 percent / K2CO3 / 12 h / Heating
2: 4 h / 100 °C
3: 2 M NaOH / 1 h / 100 °C
4: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: sodium methylate / 8 h / 20 °C / |Large scale
2: acetic acid / 90 - 100 °C / |Large scale
3: acetic anhydride; dihydrogen peroxide / water / 14 h / 0 - 45 °C
View Scheme
参考文献
Rejman, Dominik; Erbs, Jiri; Rosenberg, Ivan
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 473 - 476
