2,2-二甲基丙二酸单乙酯合成路线 （共 19 条）
反应条件
potassium hydroxide in ethanol; water T=20°C; 5 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2007/20936 A1, 2007 ;
Location in patent: Page/Page column 114-115 ;
WO 2007/020936 A1
反应条件
1: 2-dimethylstibanyl-2-methylpropionic acid ethyl ester With Me4ZnLi2 in tetrahydrofuran T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; 1.08333 h;
参考文献
Kayahara, Eiichi; Yamada, Hiroto; Yamago, Shigeru
Chemistry - A European Journal, 2011 , vol. 17, # 19 p. 5272 - 5280
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Tetrahedron Letters, , p. 3001 - 3004
反应条件
(i) LDA, (ii) /BRN= 385653/; Multistep reaction;
参考文献
Tetrahedron Letters, , # 32 p. 2721 - 2723
参考文献
Bulletin de la Societe Chimique de France, , vol. <3>31, p. 155
反应条件
Nalco silica sol 1060 in dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; Petroleum ether
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
Location in patent: Page/Page column ;
参考文献
Fichter; Steinbuch
Helvetica Chimica Acta, 1943 , vol. 26, p. 697
反应条件
Reaktion des Kaliumsalzes.Electrolysis;
参考文献
Fichter; Steinbuch
Helvetica Chimica Acta, 1943 , vol. 26, p. 697
参考文献
Fichter; Steinbuch
Helvetica Chimica Acta, 1943 , vol. 26, p. 697
反应条件
phosphorus pentachloride T=90°C;
参考文献
Buechi et al.
Helvetica Chimica Acta, 1952 , vol. 35, p. 75,76,77
