3-(4-乙酰基氨基苯甲酰基)丙酸合成路线 （共 13 条）
反应条件
aluminium trichloride in 1,2-dichloro-ethane
参考文献
Buss, Christopher W.; Coe, Paul L.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1997 , vol. 84, # 2 p. 119 - 126
反应条件
1: With AlCl3, aluminium chloride in DMF (N,N-dimethyl-formamide) T=80 - 90°C; Friedel Crafts reaction; 2 h; 2: With hydrogenchloride in water pH=1;
参考文献
Bourguignon, Jean-Jacques; Maitre, Michel; Klotz, Evelyne; Schmitt, Martine; Gobaille, Serge; Macher, Jean-Paul
Patent: US2005/113366 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
aluminium trichloride in N-methyl-acetamide; methanol; water
反应条件
sodium hydroxide; Pd-BaSO4 Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 75, p. 1376
反应条件
1: 94 percent / conc. HCl / 0.25 h / Heating 2: 65 percent / hydrazine hydrate / ethanol / 6 h / Heating View Scheme
参考文献
Amin, Enas Nashaat; Abdel-Alim, Abdel-Alim M.; Abdel-Moty, Samia G.; El-Shorbagi, Abdel-Naser A.; Abdel-Rahman, Mahran Sh.
Archives of Pharmacal Research, 2010 , vol. 33, # 1 p. 25 - 46
反应条件
1: H2SO4 / Heating 2: trifluoroacetic anhydride, H2O2 / CH2Cl2 / 0.25 h / Heating 3: SF4, HF / 28 h 4: H2 / 10percent Pd/C / methanol; acetic acid / 20 °C View Scheme
参考文献
Buss, Christopher W.; Coe, Paul L.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1997 , vol. 84, # 2 p. 119 - 126
反应条件
1: 62 percent / H2O / 1) room temperature, overnight, 2) steam bath, 2 h 2: conc. H2SO4 / 1 h / Heating 3: pyridine 4: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr 5: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating 6: 76 percent / 1 M aq. HCl / 1.25 h / Heating View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 62 percent / H2O / 1) room temperature, overnight, 2) steam bath, 2 h
2: conc. H2SO4 / 1 h / Heating
3: pyridine
4: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr
View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 62 percent / H2O / 1) room temperature, overnight, 2) steam bath, 2 h
2: conc. H2SO4 / 1 h / Heating
3: pyridine
4: H2 / Raney Nickel / methanol / 0.33 h / 1034.3 Torr
5: 90 percent / hydrazine hydrate / ethanol; H2O / 2 h / Heating
6: 76 percent / 1 M aq. HCl / 1.25 h / Heating
View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
hydrogenchloride in ethanol
3 h; Heating;
参考文献
Wang, Teng; Dong, Ying; Wang, Li-Chen; Chen, Zhen
Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 10 p. 641 - 646
