1: With palladium diacetate; triethylamine; triphenylphosphine; copper(l) iodide in N,N-dimethyl-formamide T=130°C; Alkylation; Heck reaction; 0.5 h; 2: With hydrogenchloride Carbonylation; 15 h;

1.1: 84 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C 2.1: triethylamine; palladium(II) acetate; triphenylphosphine / CuI / dimethylformamide / 0.5 h / 130 °C 2.2: 55 percent / 2.7M HCl / 15 h View Scheme