3-溴-2-(溴甲基)-6-氯吡啶合成路线 (共 2 条)
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
1 h; VIS-irradiation;
参考文献
Natarajan, Swaminathan R.; Wisnoski, David D.; Singh, Suresh B.; Stelmach, John E.; O'Neill, Edward A.; Schwartz, Cheryl D.; Thompson, Chris M.; Fitzgerald, Catherine E.; O'Keefe, Stephen J.; Kumar, Sanjeev; Hop, Cornelis E. C. A.; Zaller, Dennis M.; Schmatz, Dennis M.; Doherty, James B.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 2 p. 273 - 276
反应条件
1.1: sodium nitrite; concd. hydrochloric acid / 1 h / -20 °C
1.2: 48 percent / aq. sodium hydroxide / 0 - 5 °C / pH 11
2.1: 50 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 28 h / Heating
View Scheme
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574