吲哚-2,3-二羧酸二甲酯合成路线 （共 28 条）
反应条件
oxygen; palladium diacetate; acetic acid in N,N-dimethyl acetamide T=115°C; 18 h;
参考文献
GLAXOSMITHKLINE LLC; HAYDAR, Simon N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann
Patent: WO2013/43553 A1, 2013 ;
Location in patent: Page/Page column 124 ;
反应条件
oxygen; palladium diacetate; 2,2,2-trimethylacetic acid in N,N-dimethyl acetamide T=120°C;
参考文献
Shi, Zhuangzhi; Zhang, Chun; Li, Si; Pan, Delin; Ding, Shengtao; et al.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4572 - 4576
Angewandte Chemie, 2009 , vol. 121, p. 4642 - 4646
反应条件
oxygen; palladium diacetate; 2,2,2-trimethylacetic acid in N,N-dimethyl acetamide T=20 - 120°C; Mechanism; Reagent/catalystTimeSolvent;
参考文献
Shi, Zhuangzhi; Zhang, Chun; Li, Si; Pan, Delin; Ding, Shengtao; et al.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4572 - 4576
Angewandte Chemie, 2009 , vol. 121, p. 4642 - 4646
反应条件
triethylamine; palladium diacetate in N,N-dimethyl-formamide T=120°C; 3 h;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in N,N-dimethyl-formamide T=120°C;
参考文献
Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1990 , # 3 p. 215 - 218
反应条件
in methanol T=20°C; 2 h; Irradiation;
参考文献
Kurumi, Masateru; Sasaki, Kenji; Takata, Hiroko; Nakayama, Taiji
Heterocycles, 2000 , vol. 53, # 12 p. 2809 - 2819
反应条件
1: 94 percent / methanol / 2 h / Ambient temperature 2: 82 percent / Et3N / Pd(OAc)2 / dimethylformamide / 3 h / 120 °C View Scheme
参考文献
Synthesis, , # 3 p. 215 - 218
反应条件
1: 94 percent / methanol / 2 h / Ambient temperature 2: 82 percent / Et3N / Pd(OAc)2 / dimethylformamide / 3 h / 120 °C View Scheme
参考文献
Synthesis, , # 3 p. 215 - 218
反应条件
1: 85 percent / methanol / Ambient temperature 2: 69 percent / Et3N, P(2-CH3C6H4)3 / Pd(OAc)2 / dimethylformamide / 120 °C View Scheme
参考文献
Synthesis, , # 3 p. 215 - 218
反应条件
1: 82 percent / aq. sodium hydroxide / tetrahydrofuran / 3 h 2: 69 percent / benzene / 2 h / Heating 3: 99 percent / triethylamine / methanol / 2 h / Heating 4: 13 percent / hydrogen chloride / methanol / 8 h / Heating 5: 77 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / dioxane / 1 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 1 p. 121 - 127
