in diethyl ether 1 h;

1: 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating 2: 1.) 1,1'-carbonyldiimidazole / CH2Cl2 / 1.) 0 deg C, 45 min; 2.) 0 deg C to RT, 14 h View Scheme

1: 1) NaH / 1) DMF, 0 deg C, 4h 2) 0 deg C, 2h, then RT 2: 8 percent KOH / ethanol / 4 h / Heating 3: oxalyl chloride / benzene 4: 74 percent / diethyl ether / 1 h View Scheme

triethylamine; trichlorophosphate

1: 1.) LDA; 2.) HMPA 2: K2CO3 / dimethylformamide 3: glacial acetic acid, triphenylphosphine / toluene / 3.5 h / Heating 4: 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating 5: 1.) 1,1'-carbonyldiimidazole / CH2Cl2 / 1.) 0 deg C, 45 min; 2.) 0 deg C to RT, 14 h View Scheme

1: K2CO3 / dimethylformamide 2: glacial acetic acid, triphenylphosphine / toluene / 3.5 h / Heating 3: 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating 4: 1.) 1,1'-carbonyldiimidazole / CH2Cl2 / 1.) 0 deg C, 45 min; 2.) 0 deg C to RT, 14 h View Scheme

1: glacial acetic acid, triphenylphosphine / toluene / 3.5 h / Heating 2: 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating 3: 1.) 1,1'-carbonyldiimidazole / CH2Cl2 / 1.) 0 deg C, 45 min; 2.) 0 deg C to RT, 14 h View Scheme

1: oxalyl chloride / benzene 2: 74 percent / diethyl ether / 1 h View Scheme