4-(溴甲基)-2-噻吩羧酸甲酯合成路线 （共 5 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
2 h; Reflux;
参考文献
Hawker, Dustin D.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5763 - 5773
反应条件
1: With phosphorus tribromide in tetrahydrofuran
T=25°C; 1 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/24834 A1, 2006 ;
Location in patent: Page/Page column 80 ;
WO 2006/024834 A1
反应条件
1: 3-methyl thiophene With n-butyllithium in tetrahydrofuran
T=0°C;
2: methyl chloroformate in tetrahydrofuran
T=0°C; 16 h;
3: With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
17 h; Reflux;
参考文献
Suaifan, Ghadeer A.R.Y.; Goodyer, Claire L.M.; Threadgill, Michael D.
Molecules, 2010 , vol. 15, # 5 p. 3121 - 3134
反应条件
1: H2SO4 / Heating
2: NBS, dibenzoylperoxide / CCl4 / Heating
View Scheme
参考文献
Peschke, Bernd; Madsen, Kjeld; Hansen, Birgit Sehested; Johansen, Nils Langeland
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 1969 - 1972
反应条件
water; silver nitrate in 1,4-dioxane
T=20°C; 12 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2004/113281 A1, 2004 ;
Location in patent: Page 75 ;
