5-溴-4-甲基噻吩-2-羧酸合成路线 （共 6 条）
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5608082 A1, 1997 ;
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
反应条件
1: With sodium hydroxide in ethanol; water
T=80°C; 2 h;
2: With hydrogenchloride in dichloromethane; water
参考文献
MEDIVIR AB
Patent: WO2007/6714 A1, 2007 ;
Location in patent: Page/Page column 106-107 ;
反应条件
dihydrogen peroxide; aluminium trichloride in dichloromethane; water; acetonitrile
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
反应条件
bromine; acetic acid
参考文献
AGOURON PHARMACEUTICALS, MINC.
Patent: US2005/85492 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide)
T=20°C; 17 h;
参考文献
MEDIVIR AB
Patent: WO2007/6714 A1, 2007 ;
Location in patent: Page/Page column 106-107 ;
