3,5-二甲基联苯-4-胺合成路线 (共 13 条)
反应条件
(i) AlCl3, (ii) H3PO4; Multistep reaction;
参考文献
Taber,R.L. et al.
Journal of Heterocyclic Chemistry, 1965 , vol. 2, p. 181 - 187
参考文献
Hey; Jackson
Journal of the Chemical Society, 1934 , p. 645,648
反应条件
1: With hydrogen bromide; sodium sulfite; copper in water
T=0°C; 2 h; Heating / reflux;
2: With sodium hydroxide in water; toluene
参考文献
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
Patent: EP1602645 A1, 2005 ;
Location in patent: Page/Page column 14 ;
EP 1602645 A1