[(3,5 二甲氧基苯基)磺酰基]甲酰胺合成路线 （共 6 条）
反应条件
1: 99 percent / KOH / methanol / Heating 2: 98 percent / KOH / 60 °C View Scheme
参考文献
Wolfers,H. et al.
Synthesis, 1975 , p. 43 - 44
反应条件
potassium hydroxide in methanol 2 h; Reflux;
参考文献
AQUINOX PHARMACEUTICALS INC.; MACKENZIE, Lyoyd, F.; MACRURY, Thomas, B.; HARWIG, Curtis; BOGUCKI, David; RAYMOND, Jeffery, R.; PETTIGREW, Jeremy, D.; KHLEBNIKOV, Vladimir; SHAN, Rudong
Patent: WO2014/110036 A1, 2014 ;
Location in patent: Page/Page column 175 ;
反应条件
T=285°C; Newman-Kwart rearrangement; 6 h;
参考文献
Aquinox Pharmaceuticals Inc.
Patent: US2011/136802 A1, 2011 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: 66 percent / DABCO / 1-methyl-pyrrolidin-2-one / 50 °C
2: 86 percent / 1-methyl-pyrrolidin-2-one / 0.33 h / 295 °C / microwave irradiation
View Scheme
参考文献
Moseley, Jonathan D.; Lenden, Philip
Tetrahedron, 2007 , vol. 63, # 19 p. 4120 - 4125
反应条件
1: aq. KOH / methanol
2: K2CO3 / acetone
3: aq. HI
View Scheme
参考文献
Wolfers,H. et al.
Synthesis, 1975 , p. 43 - 44
反应条件
1: aq. KOH / methanol
2: K2CO3 / acetone
3: aq. HI
View Scheme
参考文献
Wolfers,H. et al.
Synthesis, 1975 , p. 43 - 44
