(15S,5Z,8Z,11Z,13E)-15-羟基二十碳四烯酸合成路线 （共 15 条）
反应条件
1: 87 percent / H2, quinoline / Lindlar catalyst / hexane / 25 °C
2: 91 percent / HF*pyridine / tetrahydrofuran / 0 - 25 °C
3: 86 percent / LiOH / tetrahydrofuran; H2O / 25 °C
View Scheme
参考文献
Nicolaou, K. C.; Ladduwahetty, Tamara; Elisseou, E. Michael
Journal of the Chemical Society, Chemical Communications, 1985 , # 22 p. 1580 - 1581
反应条件
1: 91 percent / HF*pyridine / tetrahydrofuran / 0 - 25 °C
2: 86 percent / LiOH / tetrahydrofuran; H2O / 25 °C
View Scheme
参考文献
Nicolaou, K. C.; Ladduwahetty, Tamara; Elisseou, E. Michael
Journal of the Chemical Society, Chemical Communications, 1985 , # 22 p. 1580 - 1581
反应条件
1: With Physcomitrella patens lipoxygenase PpLOX2; oxygen
pH=7.0; 0.5 h; aq. phosphate bufferEnzymatic reaction;
2: With sodium tetrahydroborate in methanol
0.5 h; enantiospecific reaction;
参考文献
Anterola, Aldwin; Goebel, Cornelia; Hornung, Ellen; Sellhorn, George; Feussner, Ivo; Grimes, Howard
Phytochemistry, 2009 , vol. 70, # 1 p. 45 - 57
反应条件
1.1: borax decahydrate; soybean lipoxidase; water; oxygen / 0.42 h / 0 - 5 °C / 1810.07 Torr / Enzymatic reaction
2.1: sodium tetrahydroborate; water / 0 - 5 °C / Inert atmosphere
2.2: pH 3 / Inert atmosphere
View Scheme
参考文献
Harrison, Paul; Jackson, Mark; Jones, Shaun; Kronig, Christel; Lennon, Ian C.; Simmonds, Shaun; Conrow, Raymond E.
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 301 - 304
反应条件
1: With Physcomitrella patens lipoxygenase PpLOX7; oxygen
pH=7.0; 0.5 h; aq. phosphate bufferEnzymatic reaction;
2: With sodium tetrahydroborate in methanol
0.5 h; enantiospecific reaction;
参考文献
Anterola, Aldwin; Goebel, Cornelia; Hornung, Ellen; Sellhorn, George; Feussner, Ivo; Grimes, Howard
Phytochemistry, 2009 , vol. 70, # 1 p. 45 - 57
