1: HCl / methanol / 40 h / 0 °C 2: diethyl ether / 20 h / Heating 3: BF3*Et2O / methanol / 2 h 4: 1) Mg, 2) COD*CuCl / 1) THF, 1,2-dibromoethan, reflux, 4 h, 2) THF, 35 deg C, 20 min 5: 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min View Scheme

potassium cyanide in ethanol; water T=60°C; 12 h;

in dimethyl sulfoxide T=60°C; 0.5 h; Inert atmosphere;

in dimethyl sulfoxide T=60 - 70°C; 0.5 h;

magnesium 1.) THF, -78 deg C, 51 min, 2.) from -78 deg C to RT, 1 h; Yield given. Multistep reaction;